Description：

HPI-4 (Ciliobrevin A) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.

Chemical Information：

Molecular Weight (MW)		358.18
Formula		C17H9Cl2N3O2
CAS No.		302803-72-1
Solubility (25°C) *	DMSO	71 mg/mL (198.22 mM)
	Water	Insoluble
	Alcohol	1 mg/mL (2.79 mM)

Biological Activity：

Targets IC50

BRD4(1/2) 77 nM/33 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7919 mL	13.9595 mL	27.9189 mL
5 mM	0.5584 mL	2.7919 mL	5.5838 mL
10 mM	0.2792 mL	1.3959 mL	2.7919 mL
50 mM	0.0558 mL	0.2792 mL	0.5584 mL

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