Description：

AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.

Chemical Information：

Molecular Weight (MW)		430.4
Formula		C20H13F3N4O2S
CAS No.		659730-32-2
Solubility (25°C) *	DMSO	86 mg/mL (199.81 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

B-RafV600E c-Raf-1Y340D/Y3 13 nM 6.7 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3234 mL	11.6171 mL	23.2342 mL
5 mM	0.4647 mL	2.3234 mL	4.6468 mL
10 mM	0.2323 mL	1.1617 mL	2.3234 mL
50 mM	0.0465 mL	0.2323 mL	0.4647 mL

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