Description：

Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

Chemical Information：

Molecular Weight (MW)		539.69
Formula		C31H33N5O2S
CAS No.		1129403-56-0
Solubility (25°C) *	DMSO	14 mg/mL (25.94 mM)
	Water	Insoluble
	Alcohol	1 mg/mL (1.85 mM)

Biological Activity：

Targets IC50

ErbB2 EGFR JAK2 13.5 μM 0.1 μM ~10 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8529 mL	9.2646 mL	18.5292 mL
5 mM	0.3706 mL	1.8529 mL	3.7058 mL
10 mM	0.1853 mL	0.9265 mL	1.8529 mL
50 mM	0.0371 mL	0.1853 mL	0.3706 mL

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