Description：

Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and K_i of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.

Chemical Information：

Molecular Weight (MW)		545.53
Formula		C25H22F3N5O4S
CAS No.		848141-11-7
Solubility (25°C) *	DMSO	100 mg/mL (183.3 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Aurora A 1.2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8331 mL	9.1654 mL	18.3308 mL
5 mM	0.3666 mL	1.8331 mL	3.6662 mL
10 mM	0.1833 mL	0.9165 mL	1.8331 mL
50 mM	0.0367 mL	0.1833 mL	0.3666 mL

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